I have a vet appointment tomorrow to figure it out. Seizures are going on two hours.. I've read that simparica takes 35 days to get out of their system. Call the FDA. This will kill fleas and ticks. but wasnt allowed in with him. I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. Our baby isnt the same at all since his one and only dose of Simparica. Those with Diarrhea symptom, did it look like mucus in their pets stool? Stressing out now. Our two shih tzus are 6.5. Thankfully there have been no other side effects. Yea so what about the 10 percent? My miniature Dash hound did not pull out. My 12 yr-old Chihuahua mix is losing his hair right above his nose. He wasnt throwing up at all until he received this medication. Hoping we dont have any more issues and will not be giving this again. She's pacing and wants to eat grass. Really? Before he took his first doe of Simparica he was fast running, and flying through the house and yard. Vet thinks it may be Addision disease and wants to test for it. She will never have this again, I can assure you! Any advice on the diarrhea? It may be that he is getting older as he is now one years old and he was neutered about three months ago. No more of this junk for my pups! this is how Simparica works on insects who bite your dog. It is really eye-opening to see everyone's experiences. So from what I understand, your dog was on this for 6 months and got the serious symptoms after that? My beautiful boxer lost his appetite after just one dose of Simparica. In our case the damage was permanent. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Later in the fall I noticed some leg tremors when she squatted. He is fully housebroken and just had a running stool accident in the house. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. Humans are another matter. Some are also approved for treatment and control of ear mite infestations and some gastrointestinal parasite infections, and a few are also approved for prevention of heartworm disease. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. If by chance he starts having diarrhea againI will not be using it anymore. Omg Im feeling sick seeing all these bad comments. Very "out of it". The representative for the company says the half life is 16 days. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. Gave our 23 month old Black Lab. Some pets fare better with topical solutions instead of chewables. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. Them I took him to a vet for check up and to my horror, he has fleas and a tick. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. How do I get this out of his system and what are you using instead? Don't trust your vet, do your own research. Exactly. We are closely monitoring him. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Daily Paws is part of the Meredith National Digital Network. Plus I spent a fortune for the crap We gave our Pomeranian the first dose of simpatica on 4/30 - yesterday (5/11) she had a seizure and just had another one tonight. I advise all pet owners to know the side effects. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? Sunday, he was lethargic and refused to eat. First time for this adverse reaction. She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. My personal dog has had no issues at all, and she's been on it for nearly two years. Argh. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. now almost exactly two months later, sick again with a fever and stops eating. Doubtful our dog will be given Simparica again. 300+ Cute Cat Names for Every Kind of Kitty. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. I'm so scared. Severity: Severity is mild to moderate to severe Read more. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . I will do anything to stop this from hurting or killing anyone else's baby. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. I PRAY that our baby is okay with this second dose. Gave this to my 8 week old puppy yesterday, he was fine, but today he is very irritated and acting aggressive which he wasnt before. He was lethargic & laying in his crate alot . $37.98 with Subscribe & Save discount. Its been 3 months and she continues to have them. My dog is 9 yrs old . I started giving my aussie shepherd simparica at 4 months. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. I took him to the emergency hosp. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. He was very anxious when I left him and picked him up. And it looks like the liver and/or the kidney will not take it too. Vet gave her a shot which stopped it. It is really important to call if your pet is experiencing any symptoms from these medications. There was no clear diagnosis but it was clearly neurological. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. Good appetite and no digestive issues (never had that symptom). Sound familiar? As per chewable tablets, this medicine is safe for all breeds of dogs. she has shaking off and on . We rescued another dog. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. Im so upset with myself. He does well on Simparica trio and also has the Lyme shot ? He also got that odd cough here and there that I read someone else mention. It was 11:30 pm . Within 24 hours, he would not leave my bedroom, slept all day, no appetite. This is because it doesn't kill adult heartworms. Buddy 8 year old male Boxer formerly energetic and playful. Our vet pushed this new drug for this tick season claiming the drug we used previously they had 11 dogs in the previous year were diagnosed with Lyme disease and they no longer had confidence in that drug. His immune system is destroying his red blood cells . Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. She was ok for awhile, then she had a seizure and started throwing up all over the house. Sorry man, that is horrible. Don't risk the well-being of your beloved dog just because something is more convenient. It can also cause seizures and tremors, but those side effects are incredibly rare. But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. I threw him his ball and he actually was interested in it. Thanks Michelle! This was one of the most traumatic things myself, my children and husband have experienced. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. It's been a little over two months since her last dose and feel certain that is what almost killed her. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. Then she started having tremors. I thought maybe he got into something. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. Took to vet and she said it could be the Simparico Trio. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. Itching has decreased immensely. She spent 4 nights at the University of Auburn emergency room and vet clinic. She started it on 7/22. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. You seem like an idiot. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Consulting vet and will not give Simparica ever again. 8 months of prednisone and around the clock nursing care at home saved her life. I gave the 1st one to my dog, 1st of this month. It causes paralysis that leads to death of hookworms and roundworms. He had a problem with severe biting a few months back and Vet said he most likely allergic to fleas (bites). She went on 2 antibiotics, and medicated baths twice a week. Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. My dog steadily went downhill after I gave her the first dose of simparica. Thank you to all of you posting and I hope all of your babies are doing well. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. Other signs may include: Lethargy Loss of appetite 3 months ago he began having seizures, he had one every day for a week. Then she lost control of her legs and couldn't walk or stand. He developed these big sores which scab over quickly, hair falling out here and there. My dog has had 3 seizures in the past from wearing a flea collar. If she recovers, cause is the Simparica. My 11 year old mini Aussie has been taking Simparica 1.5 years. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. The other has had diarrhea every since 6 hours after the pill. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. Today was my 14 year old Jack Russell's 2nd dose of Simparica, her name is Rallye. Does anyone know of anything we can give her to help get this out of her system? We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. My other two dogs had a little loose stool but nothing else. If anyone has discovered what can help please let me know. X-rays fine. He woke up and seemed much brighter. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. I've sent this thread and loads of other information to my vet and zoetis. Took her to her Vet where I was told she had another tremor. For 5 years I have resisted my veterinarians suggestions for oral flea meds. What is Simparica Trio for dogs? Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. On Jan 4th for the first time. The following list includes the known side effects of Simparica. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. She would constantly twirl in left circles. Thank you all so much!!!! Does any one think this could be a reaction to Simparico Trio? Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). 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